I think you dont have to worry much as there is nothing special for the admin to do while configuring the SELinux in Fedora. Yet, here are some of things that needs some care from the admin
a. Booleans: This allows the user to configure system according to the requirement of the admin, with slight alterations in the policies.
b. Setting customizable file contexts: This will allow the admin to view the security context stored in the extended attribute of the file.
c. Manage libraries work: Manage the libraries in an efficient way so that it does not break the memory protection offered by SELinux.